European journal of medicinal chemistry

Synthesis and antinociceptive activity of some substituted-{5-[2-(1, 2, 3, 4-tetrahydrocarbazol-9-yl) ethyl] tetrazol-1-yl} alkanones

A Rajasekaran, PP Thampi

Index: Rajasekaran; Thampi European Journal of Medicinal Chemistry, 2005 , vol. 40, # 12 p. 1359 - 1364

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Citation Number: 26

Abstract

Twelve different derivatives of substituted-{5-[2-(1, 2, 3, 4-tetrahydrocarbazol-9-yl) ethyl] tetrazol-1-yl} alkanones (3–14) were synthesized by reacting 9-[2-(1H-tetrazol-5-yl)-ethyl]-2, 3, 4, 9-tetrahydro-1H-carbazole (2) and the appropriate acid chlorides. 9-[2-(1H-tetrazol-5-yl) ethyl]-2, 3, 4, 9-tetrahydro-1H-carbazole (2) was synthesized by reacting 3-(1, 2, 3, 4- tetrahydrocarbazol-9-yl) propionitrile (1) with sodium azide and ammonium chloride. The ...