Click chemistry approach: Regioselective one-pot synthesis of some new 8-trifluoromethylquinoline based 1, 2, 3-triazoles as potent antimicrobial agents

B Garudachari, AM Isloor, MN Satyanarayana…

Index: Garudachari; Isloor, Arun M.; Satyanarayana; Fun, Hoong-Kun; Hegde, Gurumurthy European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 324 - 332

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Citation Number: 19

Abstract

Abstract Three series of 8-trifluoromethylquinoline based 1, 2, 3-triazoles derivatives (5a–c, 6a–d and 7a–c) were synthesized by multi-step reactions by click chemistry approach. Synthesized compounds were characterized by spectral studies and X-ray analysis. The final compounds were screened for their in-vitro antimicrobial activity by well plate method (zone of inhibition). Compounds 5c, 6b, 8b, 11 and 12 were found to be active against ...