Synthesis and pharmacological activity of pyrroloindole and bisindole quaternary ammonium salts

…, BA Medvedev, DO Kadzhrishvili, DM Tabidze…

Index: Samsonia, Sh. A.; Medvedev, B. A.; Kadzhrishvili, D. O.; Tabidze, D. M.; Mashkovskii, M. D.; Suvorov, N. N. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 11 p. 830 - 833 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 11 p. 1335 - 1338

Full Text: HTML

Citation Number: 0

Abstract

We have shown in a previous communication [i] that certain bisindole quaternary ammonium salts possess curariform activity. In continuation of these studies, we have synthesized the bisgramines (VI-X) by reacting the bis-(5-indolyl) oxide (I), its 2, 2'-diethoxycarbonyl derivative (II)[2], and the pyrroloindoles (III-V)[3] with the Mannich reagent.-? jO. o~ o _ o~ to~,~