Abstract Two types of cyclic polythiophospholipid conjugated with N1-(2-fu ran idyl)-N3-(2- hydroxyethyl)-5-fluorouracil were synthesized. The hexaethyl phosphorous triamide, activated by a catalytic amount of iodine, was used as the phosphorylating reagent in a one- pot reaction resulting in a number of novel phospholipid-drug conjugates.
