Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo [3.1. 0] hexane-2, 6-dicarboxylic acid …

A Nakazato, K Sakagami, A Yasuhara…

Index: Nakazato, Atsuro; Sakagami, Kazunari; Yasuhara, Akito; Ohta, Hiroshi; Yoshikawa, Ryoko; Itoh, Manabu; Nakamura, Masato; Chaki, Shigeyuki Journal of Medicinal Chemistry, 2004 , vol. 47, # 18 p. 4570 - 4587

Full Text: HTML

Citation Number: 44

Abstract

Novel group II metabotropic glutamate receptor (mGluR) antagonists, 3-alkoxy-2-amino-6- fluorobicyclo [3.1. 0] hexane-2, 6-dicarboxylic acid derivatives 11 and 12, were discovered by the incorporation of a hydroxy or alkoxyl group onto the C-3 portion of selective and potent group II mGluR agonist 5,(1 R, 2 S, 5 R, 6 R)-2-amino-6-fluorobicyclo [3.1. 0] hexane- 2, 6-dicarboxylic acid. Among these compounds,(1 R, 2 R, 3 R, 5 R, 6 R)-2-amino-3-(3, 4- ...