1-Substitution derivatives of 4-aryl-2, 3-dibromo-1-naphthol

J Křepelka, J Roubík, J Holubek

Index: Krepelka, Jiri; Roubik, Jiri; Holubek, Jiri Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 9 p. 2116 - 2122

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Abstract

Abstract Alkylation of 7-ethyl-4-(4-ethylphenyl)-2, 3-dibromo-1-naphthol (I) with ethyl esters of ω-bromoalkanoic acids XX-XXIII in a non-aqueous medium gave the 1-substitution derivatives II, IV, VI and VIII which were hydrolyzed to the acids III, V, VII and IX. The acid III was used for syntheses of the esters X-XIII and amides XIV-XVIII. Compounds II-XVIII exhibited moderate antineoplastic effects in animals with transplanted tumours; best ...