Tetrahedron letters

A novel dealkylation affording 3-aminoimidazo [1, 2-a] pyridines: access to new substitution patterns by solid-phase synthesis

C Blackburn, B Guan

Index: Blackburn, Christopher; Guan, Bing Tetrahedron Letters, 2000 , vol. 41, # 10 p. 1495 - 1500

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Citation Number: 79

Abstract

The three-component synthesis of 3-aminoimidazo [1, 2-a] pyridine derivatives has been extended by a novel acid-induced dealkyation reaction that removes the 1, 1, 3, 3- tetramethylbutyl group derived from the isonitrile input. This reaction was conducted on the solid-phase using the HMBA linker and the resulting products subjected to reductive alkylation using several aldehydes, thereby accessing novel substitution patterns at the 3- ...