Journal of medicinal chemistry

1H-2-Benzopyran-1-one derivatives, microbial products with pharmacological activity. Relationship between structure and activity in 6-[[1S-(3S, 4-dihydro-8-hydroxy-1 …

Y Shimojima, H Hayashi

Index: Shimojima, Yukiji; Hayashi, Hiroshi Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1370 - 1374

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Citation Number: 45

Abstract

[AI-77-B, 11, a product of Bacillus pumilus AI-77, nine derivatives were prepared and then tested for protective activity against stress-induced ulcers in rats. Neither the chromophore,[l- (3, 4-dihydro-8-hydroxy-l-oxo-1H-2-benzopyran-3-yl)-3-methylbutyllammonium chloride (2), nor the side-chain moiety, 4-amino-2, 3-dihydroxyhexanedioic acid (4), as separate fragments alone showed any significant activity. Hydrolysis of the lactone ring of the 1H-2- ...