Monocyte chemoattractant protein-1 (MCP-1, CCL2), included within the CC class of chemokines,(1) mediates chemotaxis of monocytes to inflammatory sites via interactions with its receptor, CCR2.(2) CCR2, a member of the G-protein-coupled seven-transmembrane receptor superfamily, is most abundantly expressed on monocytes. The CCL2/CCR2 axis has been implicated in various autoimmune or inflammation associated diseases(3-12) including rheumatoid ...
