e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Reactions of N, N-(dialkyl) arylthioacetamides with dialkyl acetylenedicarboxylates
MF Kosterina, YY Morzherin, AV Tkachev…
Index: Kosterina, M. F.; Morzherin, Yu. Yu.; Tkachev, A. V.; Rybalova, T. V.; Gatilov, Yu. V.; Bakulev, V. A. Russian Chemical Bulletin, 2002 , vol. 51, # 4 p. 653 - 658 Izvestiya Akademi Nauk, Seriya Khimicheskaya, 2002 , # 4 p. 604 - 608
Abstract 2-(Alkoxycarbonylmethylidene)-4-aryl-5-(dialkylamino) thiophen-3 (2 H)-ones were synthesized by condensation of N, N-(dialkyl) arylthioacetamides with dialkyl acetylenedicarboxylates. Intermediate substituted vinylic sulfides were isolated. When heated or in the presence of an acid or a base, they undergo cyclization into thiophenes.
[Valdez-Rojas, Jose Ernesto; Rios-Guerra, Hulme; Ramirez-Sanchez, Alma Leticia; Garcia-Gonzalez, Guadalupe; Alvarez-Toledano, Cecilio; Lopez-Cortes, Jose Guadalupe; Toscano, Ruben A.; Penieres-Carrillo, Jose Guillermo Canadian Journal of Chemistry, 2012 , vol. 90, # 7 p. 567 - 573]
