Synthesis, enzymatic phosphorylation and antiviral activity of acyclic dienyl phosphonate derivatives of guanine

…, PJ Casara, DL Taylor, AS Tyms, M Kenny…

Index: Nave, Jean-Francois; Casara, Patrick J.; Taylor, Debra L.; Tyms, A. Stanley; Kenny, Michael; Halazy, Serge Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 2 p. 179 - 184

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Citation Number: 10

Abstract

The synthesis, phosphorylation by guanylate kinase, anti HIV-1 and anti-herpesvirus activity of two acyclic dienyl phosphonate derivatives of guanine are described.(E)-9-(5-phosphono- 3-methylene-4-pentenyl) guanine (4) was identified as an excellent substrate of guanylate kinase and a significant inhibitor of HIV-1 replication.