Synthesis and psychotropic activity of new 1, 10-trimethylene-1, 2, 3, 4-tetrahydropyrazino (1, 2-a) indole derivatives

…, ES Krichevskii, MD Mashkovskii, NI Andreeva

Index: Grinev, A. N.; Romanova, O. B.; Krichevskii, E. S.; Mashkovskii, M. D.; Andreeva, N. I. Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 8 p. 527 - 532 Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 8 p. 3 - 37

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Abstract

We have continued our search for analogs of the psychotropic preparation pyrazidole [i] by synthesizing some hitherto inaccessible l, lO-trimethylene-2-alkyl-l, 2, 3, 4- tetrahydropyrazino (l, 2-a) indoles (Ia-p) with different substituents in positions 6, 7, and 8 and examining them in tests of psychotropi c activity. The starting compounds were 7-chloro- (IIa), 8-methyl-(IIb), 8-bromo-(IIc), and 8-chloro-l, 10-trimethylenepyrazino (l, 2-a) indole ( ...