Gadolinium DO3A derivatives mimicking phospholipids; preparation and in vitro evaluation as pH responsive MRI contrast agents

…, C Gløgård, AJ Aasen, J Klaveness

Index: Hovland; Glogard; Aasen; Klaveness Journal of the Chemical Society, Perkin Transactions 2, 2001 , # 6 p. 929 - 933

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Citation Number: 60

Abstract

A series of Gd-DO3A derivatives (8a–d) mimicking phospholipids have been prepared. Two of the complexes, Gd-HADB-DO3A (8a) and Gd-HADO-DO3A (8b), have been evaluated as pH responsive MRI contrast agents in vitro. The T1-relaxivity (r1) of Gd-HADO-DO3A (8b) increased 142% on changing the pH from 6 to 8. The pH dependence is thought to arise from the formation of supramolecular structures caused by deprotonation of the ...