Organic letters

Efficient syntheses of crispine A and harmicine by Rh-catalyzed cyclohydrocarbonylation

WH Chiou, GH Lin, CC Hsu, SJ Chaterpaul…

Index: Chiou, Wen-Hua; Lin, Gau-Hong; Hsu, Che-Cheng; Chaterpaul, Stephen J.; Ojima, Iwao Organic Letters, 2009 , vol. 11, # 12 p. 2659 - 2662

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Citation Number: 58

Abstract

The first examples of Rh-catalyzed cyclohydrocarbonylation-bicyclization of N-allylic amides of arylacetic acids are reported. This novel carbonylative bicyclization process was successfully applied to the rapid syntheses of crispine A and its analogues (tricyclic indolizidine alkaloids) as well as harmicine (tetracyclic β-carboline alkaloid).