Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity

R Bort, X Ponsoda, R Jover, MJ Gómez-Lechón…

Index: Bort, Roque; Ponsoda, Xavier; Jover, Ramiro; Gomez-Lechon, M. Jose; Castell, Jose V. Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 1 p. 65 - 72

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Citation Number: 214

Abstract

Abstract Diclofenac, a 2-arylacetic acid, nonsteroidal anti-inflammatory drug, has been reported to cause adverse hepatic effects in certain individuals. To discriminate among possible mechanisms of hepatotoxicity, we examined the effects of diclofenac on human and rat hepatocytes and hepatic cell lines (HepG2, FaO), investigated the major biochemical events in the course of diclofenac cytotoxicity (calcium homeostasis, lipid peroxidation, ...