New potent sialyltransferase inhibitors—synthesis of donor and of transition??state analogues of sialyl donor CMP??Neu5Ac

…, C Schaub, B Müller, RR Schmidt

Index: Amann, Franz; Schaub, Christoph; Mueller, Bernd; Schmidt, Richard R. Chemistry - A European Journal, 1998 , vol. 4, # 6 p. 1106 - 1115

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Citation Number: 65

Abstract

Abstract New concepts for substrate-and transition-state-derived sialyltransferase inhibitors are deduced from enzymatic sialyl transfer with CMP-Neu5Ac as donor substrate. On this basis, transition-state analogue (R)-1 was synthesized, which inhibits α (2–6)- sialyltransferase from rat liver, an important lead for further investigations.