Letters in Organic Chemistry

Tandem Generation and Trapping of Furo [3, 4-c] isoquinoline Intermediates Leading to the Synthesis of Phenanthridine Ring Systems

GP Jana, BK Ghorai

Index: Jana, Gouranga P.; Ghorai, Binay K. Letters in Organic Chemistry, 2009 , vol. 6, # 5 p. 372 - 376

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Abstract

One pot three component coupling of 3-alkynyl-4-isoquinoline carbonyl derivatives with Fischer carbene complexes and dienophiles leading to the synthesis of phenanthridine ring system has been investigated. This reaction involves the generation of furo [3, 4-c] isoquinolines as transient intermediates, which undergo [4+ 2] cycloaddition with a dienophile in an inter/intramolecular fashion. In fact, this is the first report of the work on ...