Journal of the American Chemical Society

Analogs of Benadryl

FF Blicke, GR Toy

Index: Blicke; Toy Journal of the American Chemical Society, 1954 , vol. 76, p. 4615

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Citation Number: 1

Abstract

Experimental Benzhydryl p-(1-Hexamethylenimino)-ethyl Ether.-A mixture of 18.5 g. of p-(l- he~ amethylenimino) ethanol,~ 37.1 g. of br~ modiphenylmethane~ arid 16.6 g. of anhydrous potassium carbonate was stirred and heated at 150-160" for 4 hours in a nitrogen atmosphere. Ii'zater (100 cc.) was atltletl to the cold mixture which was then extracted with ether. The extract was shaken with three 60-cc. portions of,? To hydrochloric acid. The ...