New groups of potential antituberculotics: 3-aryl-2H, 4H-benz [e][1, 3] oxazine-2, 4-diones. Comparison of the Topliss approach with regression analysis

…, L Kubicová, V Klimešová, Ž Odlerová

Index: Waisser, Karel; Kubicova, Lenka; Klimesova, Vera; Odlerova, Zelmira Collection of Czechoslovak Chemical Communications, 1993 , vol. 58, # 12 p. 2977 - 2982

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Citation Number: 10

Abstract

Abstract 3-Phenyl-2H, 4H-benz [e][1, 3] oxazine-2, 4-dione (I) and its derivatives II-XI, substituted on the phenyl ring, can be regarded as a new group of potential antituberculotics. Their activity increases with increasing electron-accepting properties of the substituents. introduction of bromine into the position 6 also positively influences the activity. the compounds are active in vitro against Mycobacterium tuberculosis and M. kansasii. ...