The synthesis and CysLT 1 antagonistic activities of a new series of 2-, 3-, and 4-(2- quinolinylmethoxy)-and 3-and 4-[2-(2-quinolinyl) ethenyl]-substituted, 2'-, 3'-, 4'-, or 5'- carboxylated chalcones are described. Structure-activity relationship studies indicate a preference for the presence of a negatively charged (acidic) moiety, although in some cases nitrile or ester analogues also exhibit moderate activity. The quinoline moiety may be ...
