In view of the well-known fact that the benzene iiucleus of physiologically active aromatic conipounds can be replaced by the thiophene nucleus without changing the character of the activity, it is of interest to synthesize and determine the activity against bacteria of thiophene analogs of sulfanilamide. Of the six possible isomers, 5-amino-2-thiophenesulfonamide may be considered to be related most closely to sulfanilamide in that the 5-position in ...
