Synthesis and DNA cleavage activity of triazacrown-anthraquinone conjugates

W Xu, X Yang, L Yang, ZL Jia, L Wei, F Liu…

Index: Xu, Weihong; Yang, Xiaoli; Yang, Lian; Jia, Zhao-Li; Wei, Li; Liu, Fang; Lu, Guo-Yuan New Journal of Chemistry, 2010 , vol. 34, # 11 p. 2654 - 2661

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Citation Number: 11

Abstract

1, 4, 7-Triazacyclononane (TACN), with DNA cleaving ability, was appended to anthraquinone via different spacers to construct the new compounds 1, 8-[2, 2′-(1, 4, 7- triazacyclonon) diethoxy] anthracene-9, 10-dione hydrochloride (1) and 1, 8-[2, 2′-(1, 4, 7- triazacyclonon) dihexyloxy] anthracene-9, 10-dione hydrochloride (2) as new agents for metal-free DNA cleavage. Fluorescence and CD spectroscopic studies suggest an ...