Development of dual-acting benzofurans for thromboxane A2 receptor antagonist and prostacyclin receptor agonist: synthesis, structure-activity relationship, and …

…, K Hoshi, T Takeda, N Yamada, A Ohtake

Index: Ohno, Michihiro; Miyamoto, Mitsuko; Hoshi, Kazuhiro; Takeda, Takahiro; Yamada, Naohiro; Ohtake, Atsushi Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5279 - 5294

Full Text: HTML

Citation Number: 22

Abstract

Prostacyclin (PGI2) is an unstable, powerful endogenous inhibitor of platelet aggregation, and thromboxane A2 (TXA2) is an unstable endogenous arachidonic acid metabolite that plays a pivotal role in platelet aggregation and vasoconstriction. The balance between TXA2 and PGI2 greatly affects maintenance of the homeostasis of the circulatory system. A novel series of benzofuran-7-yloxyacetic acid derivatives was discovered as potent dual-acting ...