Nonsteroidal antiinflammatory agents. 14. synthesis and pharmacological profile of 6-chloro-5-(cyclopentylmethyl) indan-1-carboxylic acid

…, G Kirsch, F Siegmund, H Wachtel

Index: Boettcher, Irmgard; Elger, Walter; Kirsch, Gerald; Siegmund, Fred; Wachtel, Helmut Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 413 - 414

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Citation Number: 5

Abstract

The most common side effects of acidic nonsteroidal antiinflammatory drugs in man, as well as in animals, are gastrointestinal symptoms, ie, mucosal damage, bleeding, and ulceration. 2 Therefore, the therapeutic use of the drugs is very often limited by their gastrointestinal intolerability. One of the most important goals of research activities in this field is the development of potent antiinflammatory drugs with very low or even no gastrointestinal ...