Tetrahedron Letters

Rapid access to cis-cyclobutane γ-amino acids in enantiomerically pure form

V André, A Vidal, J Ollivier, S Robin, DJ Aitken

Index: Andre, Virginie; Vidal, Anne; Ollivier, Jean; Robin, Sylvie; Aitken, David J. Tetrahedron Letters, 2011 , vol. 52, # 12 p. 1253 - 1255

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Citation Number: 14

Abstract

The (+)-(1R, 2S) and (−)-(1S, 2R) stereoisomers of 2-(aminomethyl) cyclobutane-1- carboxylic acid have been prepared using a short and efficient strategy, which employs the photochemical [2+ 2] cycloaddition reaction between ethylene and an unsaturated γ-lactam as the key step.