Tetrahedron letters

Reversal of the regioselectivity of anthrapyrazole formation. A new synthesis of losoxantrone (DUP941)

L Zhang, WE Meier, EJ Watson, EP Gibson

Index: Zhang, Lin-Hua; Meier, Walter E.; Watson, Elton J.; Gibson, Emily P. Tetrahedron Letters, 1994 , vol. 35, # 22 p. 3675 - 3678

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Citation Number: 16

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Losoxantrone, a potent anticancer agent, has been efficiently synthesized in a 6 step process from 5-hydroxy-1,4-dichloroanthracene-9,10-dione. ... A new efficient synthesis of losoxantrone is reported. ... 8: mp. 178-80°C; 1 H NMR (300 MHz, DMSO) δ 4.20 (2H, t, J = 4.8 Hz), 5.0 ...