The highly constitutively active G-protein coupled receptor US28 of human cytomegalovirus (HCMV) is an interesting pharmacological target because of its implication on viral dissemination, cardiovascular diseases and tumorigenesis. We found that dihydroisoquinolinone and tetrahydroisoquinoline scaffolds may be promising lead structures for novel US28 allosteric inverse agonists. These scaffolds were rapidly ...
[Grunewald, Gary L.; Romero, F. Anthony; Chieu, Alex D.; Fincham, Kelcie J.; Bhat, Seema R.; Criscione, Kevin R. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 4 p. 1261 - 1273]
