Evaluation of Novel Synthetic Methods for the Preparation of the Sodium Channel Inhibitor, GW273225X

MD Walker, FD Albinson, HF Clark…

Index: Silhar, Peter; Pohl, Radek; Votruba, Ivan; Hocek, Michal Organic and Biomolecular Chemistry, 2005 , vol. 3, # 16 p. 3001 - 3007

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Abstract

... 88. DOI: 10.1021/op4001753. Publication Date (Web): November 18, 2013. Copyright © 2013 American Chemical Society. ... The program was restarted in 2005 as a follow-up to lamotrigine 2 (Lamictal ... and 0 °C and included a range of bases (strong and weak, organic and inorganic ...

~46%

~72%

~13%

Regioselective metalation of 6-methylpurines: synthesis of f...

[Hassan, Abdalla E. A.; Parker, William B.; Allan, Paula W.; Secrist III, John A. Nucleosides, Nucleotides and Nucleic Acids, 2009 , vol. 28, # 5-7 p. 642 - 656]

Selective metalation of 6-methylpurines: Synthesis of 6-fluo...

[Hassan, Abdalla E. A.; Parker, William B.; Allan, Paula W.; Montgomery, John A.; Secrist III, John A. Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 5-8 p. 747 - 749]