The first ring-closing olefin metatheses of alkenyl α-fluoroacrylamides or acrylates incorporating a fluorinated double bond are reported. Several N-benzyl-N-alkenyl-α- fluoroacrylamides were cyclized in the presence of 2mol% of Grubbs II catalyst at room temperature to form an unsaturated γ-lactam, and at 80° C to form the corresponding δ- lactams bearing a fluoro vinyl moiety. At elevated temperature, cyclization of an N- ...
