Abstract Methyl 4, 5-diaminopentanoate (4, 5-Dape Me) undergoes competitive intramolecular aminolysis to 5-aminomethyl-2-pyrrolidinone (L5) and 5-amino-2- piperidinone (L6) in dilute alkaline aqueous solution at 25 C. Use of this single compound provides an ideal case for assessing the relative rates of 5-and 6-membered lactam ring closure. Assessments are also made using the intramolecular aminolysis of pairs of ...
