Lipophilic caffeic and ferulic acid derivatives presenting cytotoxicity against human breast cancer cells

…, T Silva, J Garrido, N Milhazes, F Borges…

Index: Roleira, Fernanda M.F.; Siquet, Christophe; Orr, Elizabeta; Garrido, E. Manuela; Garrido, Jorge; Milhazes, Nuno; Podda, Gianni; Paiva-Martins, Fatima; Reis, Salette; Carvalho, Rui A.; Silva, Elisiario J. Tavares Da; Borges, Fernanda Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 16 p. 5816 - 5825

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Citation Number: 49

Abstract

In the present work, lipophilic caffeic and ferulic acid derivatives were synthesized, and their cytotoxicity on cultured breast cancer cells was compared. A total of six compounds were initially evaluated: caffeic acid (CA), hexyl caffeate (HC), caffeoylhexylamide (HCA), ferulic acid (FA), hexyl ferulate (HF), and feruloylhexylamide (HFA). Cell proliferation, cell cycle progression, and apoptotic signaling were investigated in three human breast cancer cell ...