Inorganic chemistry

Cooperativity between metal ions in the cleavage of phosphate diesters and RNA by dinuclear Zn (II) catalysts

O Iranzo, T Elmer, JP Richard, JR Morrow

Index: Iranzo, Olga; Elmer, Terry; Richard, John P.; Morrow, Janet R. Inorganic Chemistry, 2003 , vol. 42, # 24 p. 7737 - 7746

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Citation Number: 152

Abstract

Ligands containing linked 1, 4, 7-triazacyclononanes form dinuclear Zn (II) complexes at near neutral pH. Comparison of second-order rate constants for cleavage of HPNP (2- hydroxypropyl-4-nitrophenyl phosphate) at pH 7.6, 25° C and extent of cleavage of an oligoribonucleotide suggests that only one dinuclear complex has cooperative catalysis between the Zn (II) centers. This complex has a bridging alkoxide that brings the two Zn (II) ...