The aforementioned considerations apply to substituted 1H-1,2,4-triazoles. The similar properties of C-alkyl substituents on triazoles to those on benzene are widely recognized. 6 By contrast, the reactivity of N-substituents on triazoles, as with N-substituents on heterocycles in general, has until recently been much less investigated. 6 Most studies of the lithiation of N-substituted triazoles have been in connection with the protection of the 1-NH during C-lithiation at ...
