e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Bulletin of the Chemical Society of Japan
Transformation of 3-(2, 2-dichloroethenyl)-2, 2-dimethylcyclopropanecarboxylates to the corresponding 2, 2-dibromoethenyl analogs by halogen exchange reaction
K Matsui, A Saito, K Kondo
Index: Matsui, Kiyohide; Saito, Akemi; Kondo, Kiyosi Bulletin of the Chemical Society of Japan, 1986 , vol. 59, # 4 p. 1021 - 1026
The title transformation is effected with aluminium tribromide or related reagents in over 80% yields without cis-trans isomerization or epimerization. Efficient removal of hydrogen bromide is essential for optimum yields of the desired products. Use of boron tribromide instead of aluminium tribromide results in opening of the cyclopropane ring with no halogen exchange.