Synthesis of haptens and their protein conjugates for immunological determination of nitrate esters and nitramines

…, IG Beadham, H Adams, AP Hutchinson…

Index: Blackburn, G. Michael; Beadham, Ian G.; Adams, Harry; Hutchinson, Alistair P.; Nicklin, Stephen Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 2 p. 225 - 230

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Citation Number: 14

Abstract

Isosteric, isopolar analogues of the nitrate ester pentaerythritol tetranitrate (PETN) and of the cyclic nitramine sym-cyclotrimethylene trinitramine (RDX) having a spacer arm have been linked to carrier proteins to provide immunologically active peptide conjugates. X-Ray structures of RDX, RDX analogue 10, and hapten 14 are compared to establish their conformational relationships.