The Journal of organic chemistry

Guanidine/Pd (OAc) 2-catalyzed room temperature Suzuki cross-coupling reaction in aqueous media under aerobic conditions

S Li, Y Lin, J Cao, S Zhang

Index: Li, Shenghai; Lin, Yingjie; Cao, Jungang; Zhang, Suobo Journal of Organic Chemistry, 2007 , vol. 72, # 11 p. 4067 - 4072

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Citation Number: 141

Abstract

A highly efficient Pd (OAc) 2/guanidine aqueous system for the room temperature Suzuki cross-coupling reaction has been developed. The new water-soluble and air-stable catalyst Pd (OAc) 2⊙(1f) 2 from Pd (OAc) 2 and 1, 1, 3, 3-tetramethyl-2-n-butylguanidine (1f) was synthesized and characterized by X-ray crystallography. In the presence of Pd (OAc) 2⊙(1f) 2, coupling of arylboronic acids with a wide range of aryl halides, including aryl iodides, ...