Chemistry, binding affinities, and behavioral properties of a new class of" antineophobic" mitochondrial DBI receptor complex (mDRC) ligands

AP Kozikowski, D Ma, J Brewer, S Sun…

Index: Kozikowski, A. P.; Ma, D.; Brewer, James; Sun, S.; Costa, E.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2908 - 2920

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Citation Number: 115

Abstract

The mitochondrial DBI receptor complex (mDRC; previously called the peripheral benzodiazepine receptors) is linked to the production of neurosteroids such as pregnenolone sulfate, dehydroepiandrosterone sulfate, and others. In order to gain further information as to the function of the mDRC in the brain, we have constructed and tested both in vitro and in vivo a novel series of ligands, 2-arylindole-3-acetamides. The SAR studies ...