By use of these conditions, we can catalyze the Sonogashira coupling of a wide variety of aryl bromides and terminal acetylenes at room temperature (Table 1). 12 Thus, bromobenzene reacts with an array of alkynes in good to excellent yields (entries 1−3). As illustrated in entries 4−7, less reactive 4-bromoanisole also couples with high efficiency. Even very electron-rich 4-bromo-N,N-dimethylaniline reacts cleanly at room temperature (entry 8). The coupling ...
