Imidazo [1, 2-b] pyridazines. XII. Syntheses and Central Nervous System Activities of Some Substituted Imidazo [1, 2-b] pyridazines and Related Imidazo [1, 2-a] …

GB Barlin, LP Davies, SJ Ireland, MML Ngu…

Index: Barlin, Gordon B.; Davies, Les P.; Ireland, Stephen J.; Ngu, Maria M. L.; Zhang, Jiankuo Australian Journal of Chemistry, 1992 , vol. 45, # 5 p. 877 - 888

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Citation Number: 19

Abstract

Abstract Syntheses are reported for some 6-chloro (alkoxy, alkylthio and pheny1thio)-3- benzamidomethyl-(acetamidomethyl and methoxy)-2-arylimidazo [1, 2-apyridines and some corresponding imidazo-[1, 2-b] pyridazines, imidazo [1, 2-a [pyrimidines and imidazo [l, 2-a] pyrazines. IC 50 values (or percentage displacement) are reported and discussed for the displacement of [3 H] diazepam from rat brain membrane by each of these compounds.