An efficient method for preparation of 3, 5-diamino-6-chloropyrazin-2-yl alkyl ketones using a novel acetylene hydration method

MJ Chapdelaine, PJ Warwick…

Index: Chapdelaine, Marc J.; Warwick, Paul J.; Shaw, Andrew Journal of Organic Chemistry, 1989 , vol. 54, # 5 p. 1218 - 1221

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Citation Number: 30

Abstract

Routes utilizing acid 2a and several derivatives as the immediate precursors of 1 were explored to no avail? The problems encountered during the attempted carboxyl to keto conversion led us to consider inserting the carbonyl group into 1 in masked form. The efficiency of the palladium-catalyzed coupling of aromatic iodides with monosubstituted acetylenes4s5 combined with the number of means available for hydration of acetylenes ...