Pd (0)??Catalyzed Cu (I)??Thiophene??2??carboxylate??mediated Cross??Coupling of Heteroaromatic Thioethers and Boronic Acids—First Liebeskind–Srogl Reaction in …

M Koley, L Wimmer, M Schnürch…

Index: Koley, Moumita; Wimmer, Laurin; Schnuerch, Michael; Mihovilovic, Marko D. Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1368 - 1373

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Abstract

Abstract The first example of a Liebeskind–Srogl cross-coupling reaction in water as sole reaction solvent is reported. 2-(Methylthio) pyridine and 2-(methylthio) benzothiazole were reacted in the presence of a Pd (0) catalyst and copper (I) thiophene-2-carboxylate with a series of arylboronic acids. These cross coupling reactions in water proceeded well with electron-rich boronic acids and gave comparable yields to literature examples using ...