Afri et al. reported in this journal (Free Radic. Biol. Med. 32: 605-618; 2002) that a direct relationship exists between the depth of alkanoylcoumarins 1 within the liposomal lipid bilayer and the rate at which they undergo superoxide-mediated saponification. These results were based on a correlation between the 13C NMR chemical shift of polarizable carbonyl carbons and the ET (30) polarity they sense. Subsequent studies challenged ...
