Abstract This paper describes the preparation of 5-nitro-2-furylacetylene (I), the starting material for the synthesis of 1-iodo-2-(5-nitro-2-furyl) ethylene (II), 3-(5-nitro-2-furyl) propinoic acid (III) and 1, 2-bis-(5-nitro-2-furyl)-acetylene (IX), substances possessing antibacterial properties.