Tetrahedron

Fluorine-substituted derivatives of the carcinogenic dihydrodiol and diol epoxide metabolites of 7-methyl-, 12-methyl-and 7, 12-dimethylbenz [a] anthracene

RG Harvey, C Cortez

Index: Harvey, Ronald G.; Cortez, Cecilia Tetrahedron, 1997 , vol. 53, # 21 p. 7101 - 7118

Full Text: HTML

Citation Number: 14

Abstract

Stereospecific syntheses of the trans-3, 4-dihydrodiol metabolites of 9-and 10-fluoro-7, 12- dimethylbenz [a] anthracene,-7-methylbenz [a] anthracene, and-12-methylbenz [a] anthracene are described. These dihydrodiols are putative proximate carcinogenic metabolites that undergo activation by the P-450 microsomal enzymes to ultimate carcinogenic anti-and syn-diol epoxide metabolites that bind to nucleic acids in vivo. ...