Synthesis and Structure− Activity Correlation of Natural-Product Inspired Cyclodepsipeptides Stabilizing F-Actin

R Tannert, LG Milroy, B Ellinger, TS Hu…

Index: Tannert, Rene; Milroy, Lech-Gustav; Ellinger, Bernhard; Hu, Tai-Shan; Arndt, Hans-Dieter; Waldmann, Herbert Journal of the American Chemical Society, 2010 , vol. 132, # 9 p. 3063 - 3077

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Citation Number: 58

Abstract

The fundamental role played by actin in the regulation of eukaryotic cell maintenance and motility renders it a primary target for small-molecule intervention. In this arena, a class of potent cytotoxic cyclodepsipeptide natural products has emerged over the last quarter- century to stimulate the fields of biology and chemistry with their unique actin-stabilizing properties and complex peptide− polyketide hybrid structures. Despite considerable ...