Three??Component (Domino) Reaction Affording Substituted Pyrroloquinazolines: Cyclization Regioselectivity and Stereoselectivity

O Paleta, B Dolenský, J Paleček…

Index: Paleta, Oldrich; Dolensky, Bohumil; Palecek, Jiri; Kvicala, Jaroslav European Journal of Organic Chemistry, 2013 , # 7 p. 1262 - 1270

Full Text: HTML

Citation Number: 2

Abstract

Abstract The cyclization involving 2-(aminomethyl) aniline, methyl 3, 3, 3-trifluoropyruvate, and various oxo compound afforded linearly annulated pyrroloquinazolines, for example,(2R*, 3aS*)-2-hydroxy-3a-phenyl-2-trifluoromethyl-3, 3a, 4, 9-tetrahydropyrrolo [2, 1-b] quinazolin-1 (2H)-one (cis-8), as the major product, possessing the skeleton of the alkaloids of the vasicine group, along with angularly annulated products, for example,(2S* ...

~31%

~14%

Experimental and computational studies on the mechanism of N...

[Wiedemann, Sean H.; Lewis, Jared C.; Ellman, Jonathan A.; Bergman, Robert G. Journal of the American Chemical Society, 2006 , vol. 128, # 7 p. 2452 - 2462]

4-Phenyl tetrahydroisoquinolines as dual norepinephrine and ...

[Pechulis, Anthony D.; Beck, James P.; Curry, Matt A.; Wolf, Mark A.; Harms, Arthur E.; Xi, Ning; Opalka, Chet; Sweet, Mark P.; Yang, Zhicai; Vellekoop, A. Samuel; Klos, Andrew M.; Crocker, Peter J.; Hassler, Carla; Laws, Mia; Kitchen, Douglas B.; Smith, Mark A.; Olson, Richard E.; Liu, Shuang; Molino, Bruce F. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7219 - 7222]

The Development of a Manufacturing Route for the GPIIb/IIIa ...

[Andrews, Ian P.; Atkins, Richard J.; Breen, Gary F.; Carey, John S.; Forth, Michael A.; Morgan, David O.; Shamji, Amin; Share, Andrew C.; Smith, Stephen A. C.; Walsgrove, Timothy C.; Wells, Andrew S. Organic Process Research and Development, 2003 , vol. 7, # 5 p. 655 - 662]