Journal of medicinal chemistry

Some epinephrine analogs

ED Bergmann, Z Goldschmidt

Index: Bergmann,E.D.; Goldschmidt,Z. Journal of Medicinal Chemistry, 1968 , vol. 11, # 6 p. 1121 - 1125

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Citation Number: 15

Abstract

A number of epinephrine analogs and corresponding 1-aryl-2-alkylaminoethyl chloride hydrochlorides and bromide hydrobromides have been prepared. The central intermediates of the syntheses were the 5-aryl-&alkyl-2-oxaxolidones (IV), accessible by alkylation of the product obtained using the Reformatzky reaction of an aromatic aldehyde with ethyl bromoacetate. The results of a pharmacological study of the products obtained are ...