Steroids

… of 1α, 23, 25-trihydroxy-24-oxo-19-nor-vitamin D 3: novel analogs of 1α, 23 (S), 25-trihydroxy-24-oxo-vitamin D 3, a natural metabolite of 1α, 25-dihydroxyvitamin D 3

…, PG Williard, AJ Brown, MJ Campbell, HP Koeffler…

Index: Lee, Nancy E.; Williard, Paul G.; Brown, Alex J.; Campbell, Moray J.; Koeffler, H. Phillip; Peleg, Sara; Rao, D. Sunita; Reddy, G. Satyanarayana Steroids, 2000 , vol. 65, # 5 p. 252 - 265

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Citation Number: 7

Abstract

In a previous report, we indicated that 1α, 23 (S), 25-trihydroxy-24-oxovitamin D3 [1α, 23 (S), 25 (OH) 3-24-oxo-D3], a natural metabolite of 1α, 25-dihydroxyvitamin D3 [1α, 25 (OH) 2D3] is almost equipotent to 1α, 25 (OH) 2D3 in suppressing parathyroid hormone (PTH) secretion (Lee et al., 1997. Biochemistry 36, 9429–9437). Also, 1α, 23 (S), 25 (OH) 3-24-oxo- D3 has been shown to possess only weak in vivo calcemic actions. Thus, vitamin D3 ...