Abstract: Total syntheses of three spatane diterpenes stoechospermol (I), 5 (R), 15 (R), 18- trihydroxyspata-l3, 16 (E)-diene (2), and (+)-spat01 (3) were accomplished from a common intermediate, diol 7. The total synthesis established as R the absolute configuration at the 15- position in 2. Novel stereospecific transformations of 2, 3-epoxy-1, Cdiols into vicinal diepoxides were demonstrated and exploited for assembling the sensitive allylic ...
