Novel Regiocontrolled Protection of 1, 2-and 1, 3-Diols via Mild Cleavage of Methylene Acetals

…, O Kubo, K Yahata, Y Minamitsuji, T Maegawa

Index: Fujioka, Hiromichi; Senami, Kento; Kubo, Ozora; Yahata, Kenzo; Minamitsuji, Yutaka; Maegawa, Tomohiro Organic Letters, 2009 , vol. 11, # 22 p. 5138 - 5141

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Citation Number: 10

Abstract

The regiocontrolled protection of unsymmetrical 1, 2-and 1, 3-diols has been developed. Different types of protected diols are available from the methylene acetal in a one-pot procedure. Highly regioselective protection of diols with a silyl group at the less hindered hydroxy group as well as with a MOM group at the more hindered one were achieved. The reaction conditions are mild without affecting other functional groups including acid-labile ...